He was born to Robert De Niro Sr. and Virginia Admiral. He was married to actress Diahnne Abbott from 1976 to 1988. He dated model and actress Toukie Smith from 1988 to 1996. He was married to actress Grace Hightower from 1997 to 2018.
He has two daughters named Drena De Niro (adopted) and Helen Grace De Niro (with Grace Hightower). He has four sons named Raphael De Niro (with Diahnne Abbott), Aaron Kendrick De Niro (with Toukie Smith), Julian Henry De Niro (with Toukie Smith), and Elliot De Niro (with Grace Hightower). He became the father of his 7th child in May 2023 at the age of 79. The rumor is that Tiffany Chen is the mother of his 7th child. One of his grandson Leandro De Niro Rodriguez found died on 02-07-2023, he was the only son of his daughter Drena De Niro.